The waste heat is also a significant limiting factor for nuclear, currently. In the US, we only have a limited amount of water heat sinks that we can use to dissipate waste heat, and there's limited heating allowed before we destroy those ecosystems. The figure that I heard recently was about ~500GW across the nation. After that, we will need to find other solutions, which bar often more expensive that using natural water. There's a nuclear plant in Arizona that uses water water from Phoenix, for example. But after that we will need some innovation in water heat management to overcome the natural limitations of thermal generators like nuclear, at least while on planet earth.