How my ivermectin research led to Twitter death threats
theguardian.com
theguardian.com
It'd be fascinating if it wasn't so depressing.
The idea of the pioneering research who establishes a reputation through novel work and rigorous experiments is mostly a myth. You advance when your peers like your work, which creates all the wrong incentives.
https://en.wikipedia.org/wiki/You_are_either_with_us,_or_aga...
Bingo. We're in the Attitude Era of US politics. Twitter and Facebook have allowed combative politics to break even further through the fourth wall and allow your average American to participate in the scrum.
From Wikipedia : Merck began marketing ivermectin as a veterinary antiparasitic in 1981
> In early 2021, my research team was analysing a new drug called ivermectin
Similar to me saying, my team started using a new framework called React
EDIT: missed my comparison
That doesn't work to my ear.
Ivermectin isn't new. But using it to treat a coronavirus is.
No.
Ivermectin was identified as a broad antiviral a long time ago.
A large number of papers started to emerge on Ivermectin's applicability to a number of viral infections appeared at least as early as 2012. I'm sure there must be more earlier, it is just that my search skills are bad.
There were also patents around some of these applications.
Please, do your research before you make incorrect blanket statements.
"Please respond to the strongest plausible interpretation of what someone says, not a weaker one that's easier to criticize. Assume good faith."
Would it be wise to always assume good faith in articles? I don't think so.
Finally I expect better from a newspaper as the Guardian.
You are trying to drag morality into this where I just pointed out a flaw.
The death threats and abuse on top of that...It's just so demoralizing to live in this atmosphere. If we had a functioning justice system it would find these people and charge them with fraud.
The people who are making these threats feel as though they are being persecuted by a media-corporate-legal complex that is out to get them. The more you attempt to penalize these individuals for their beliefs, the more radicalized they will become.
Does this now suddenly mean we stop enforcing the law (against financial fraud) because it might hurt their feelings?
This is dysfunction. What can we do if we're not allowed to present facts and evidence because it might trigger people? We end up walking on eggshells while the crazies take over.
It's not that simple: you can't just label an entire political faction as crazy. The left also holds viewpoints that moderates think are absolutely bonkers (which specific viewpoints I can't even say without risking a flamewar on HN), but we've been taught to be respectful of other people's opinions.
I didn't say that. It was a general statement about crazy people. Everyone has their own distortion fields; they are myriad and contradictory and situational. Please don't start with this left/right splitting and victimization stuff. There's a ton of shit I won't say on HN because it doesn't go over well. It's not a left/right thing, believe me.
What would you say if - hypothetically - an entire political faction went crazy? There are examples from history.
- https://www.niemanlab.org/2021/06/deplatforming-works-this-n...
- https://www.vice.com/en/article/bjbp9d/do-social-media-bans-...
- https://theconversation.com/does-deplatforming-work-to-curb-...
I don't even think it's that deep. These medications are just memes to fuel a shallow grift. It gives them something to talk about in between pushing for donations, that's all.
lol
https://www.nbcnews.com/tech/tech-news/ivermectin-demand-dri...
> The website advertises consultations for $90 and fills prescriptions through Ravkoo Pharmacy, an online pharmacy that America’s Frontline Doctors advertises as “partners,” who provide “the option to have that prescription delivered right to your door, the same day.” On a SpeakWithAnMD.com intake form viewed by NBC News, prospective patients are asked, “What medication do you prefer?” The user is then presented with three options: “Ivermectin,” “Hydroxychloroquine” or “Not sure.”
https://theintercept.com/2021/09/28/covid-telehealth-hydroxy...
If they work - if they are safe and effective for the given disease, then yes.
If.
Here, eat this rock. That's be $500. Look at that, another treatment option.
Critical thinking is important in medicine. You can't just trust any yahoo with medical advice.
We have no idea if Ivermectin works. The randomized trials are ongoing.
It would be great if it works. Fantastic. We should all hope that it does. If we're asking questions, let's ask this: why are people so eager to leap to the conclusion that it doesn't work?
Survivorship and confirmation bias. If a thousand doctors try it out then a few of them will statistically see incredible results. They will then be "on board", confirm amongst each other, and be skeptical any data that shows otherwise.
Plain bias. Just being anti-vax and jumping onto anything that avoids vaccination. Or being anti-government and jumping onto anything that is opposite of what CDC promotes. Or being among the anti-science variant of religious and jumping onto anything that shows religion over science.
It's not particularly these people's "fault" that they're behaving how they do. It's just human nature.
There are others that I think are doing it primarily for notoriety. Joe Rogan, Simone Gold, etc. But the thing is, the people enamored with the anti-science or anti-vax or anti-government schtick are going to find someone to champion their cause, and once you start down that path it's hard to turn back.
They care so much for exactly the same reasons you expressed in your post: because they think this is costing thousands of lives, and they have little trust in institutions that typically study these, and often for good reasons.
The same financial incentives that drive some fraudsters to push "fake treatments" are even greater in pharma where literally billions of dollars are on the line, which is why people's skepticism of pharma is so significant.
You see how much symmetry there is in how you're thinking about this and how the people on the other side are thinking about this. The only way to come to a common understanding is to agree on who can ascertain the truth on these questions, and so the loss of institutional trust is the real problem here.
Journalists these days are viewed as partisan hacks, and science journalism has been almost universally terrible for decades now anyway, so arguably people have no reason to trust journalists.
Scientists are much better on factual questions generally, but even here the replication crisis has shown that up to 50% of published results can't be replicated [1], so a coin flip would be equally likely to ascertain the truth on any new question. Fixing this has only just begun and the remedies will take years to be adopted everywhere.
This reckoning has been a long time coming, but people are so caught up in their partisan politicking they're missing the forest for the trees and putting the blame in all the wrong places.
[1] Edit: 50% in medicine, it's even worse in other disciplines like social sciences.
They could rather study a country like india where some states prescribed Ivermectin and other state didnt and see what the results were like.
L
A large clinical trial from June 2020 has shown no clinical benefit to hydroxychloroquine in hospitalised patients with COVID-19
No clinical benefit from use of hydroxychloroquine in hospitalised patients with COVID-19: https://www.recoverytrial.net/news/statement-from-the-chief-...
From the above:
> A total of 1542 patients were randomised to hydroxychloroquine and compared with 3132 patients randomised to usual care alone. There was no significant difference in the primary endpoint of 28-day mortality (25.7% hydroxychloroquine vs. 23.5% usual care; hazard ratio 1.11 [95% confidence interval 0.98-1.26]; p=0.10). There was also no evidence of beneficial effects on hospital stay duration or other outcomes.
> These data convincingly rule out any meaningful mortality benefit of hydroxychloroquine in patients hospitalised with COVID-19.
To give you an example, here is one systematic review of hydroxychloroquine effectiveness with covid: https://pubmed.ncbi.nlm.nih.gov/33042552/
Again, one study does not prove or disprove a hypothesis, but cherry-picking one study as evidence that my argument is wrong is certainly not how science works. However, it is interesting that hydroxychloroquine has been shown to work better in non-hospitalized or pre-hospitalized patients, which makes sense given covid's mechanism of action. The anti-parasitics essentially protect the red blood cells from infection, so I wouldn't be surprised if that is the reason why they may work better in non-hospitalized patients.
But...I don't have time to do a meta-analysis for people that aren't open to finding the truth, regardless of what political agenda the truth may support or not support.
Good luck to everyone so invested in proving or disproving each other's arguments. I've wasted enough time - now back to my work.
"Ivermectin for Prevention and Treatment of COVID-19 Infection: A Systematic Review, Meta-analysis, and Trial Sequential Analysis to Inform Clinical Guidelines"
https://journals.lww.com/americantherapeutics/fulltext/2021/...
Conclusions:
"Moderate-certainty evidence finds that large reductions in COVID-19 deaths are possible using ivermectin. Using ivermectin early in the clinical course may reduce numbers progressing to severe disease. The apparent safety and low cost suggest that ivermectin is likely to have a significant impact on the SARS-CoV-2 pandemic globally."
However as this article mentions:
https://www.theguardian.com/science/2021/jul/16/huge-study-s...
One large part of the meta analysis and the list of studies included, had also the Elgazzar study and this was one of the discredited studies. It is also claimed, as the Elgazzar study was so large, and massively positive, it would skew the evidence in favor of ivermectin. As far as I know, so far these statements were made by respected practitioners, but no statistical peer reviewed meta-studies to support their claims have been published until now.
I would wait for the results of the highly respected, Oxford led, Principle study:
https://www.principletrial.org/
https://www.principletrial.org/news/ivermectin-to-be-investi...
So far there were able to conclusively confirm the asthma drug budesonide shortens recovery time in non-hospitalised patients with COVID-19 :
https://www.principletrial.org/news/asthma-drug-budesonide-s...
They were also able to dismiss Azithromycin, Colchicine and Doxycycline as having no helpful effect.
https://www.principletrial.org/results
There is plenty of appalling behavior to fuel keyboard warriors, on both sides. The BBC and CNN have not behaved much better:
I wish they would just present raw numbers of X vs Y without trying to push a view (even if it's a view I agree with). But, that doesn't generate the clicks they need to fund themselves. And of course, "lies, damn lies, and statistics", IDK whether there's a way to present data completely neutrally, but they could at least try.
Some people now feel that taking livestock deworming pills is safer than being vaccinated. As if a vaccine is inherently dangerous and that taking a horse pill is safe.
News flash:
* Taking random animal medicine in any form is inherently risky.
* Overdosing on pills designed to deliver medicine to 1000 lbs animals is unreasonably likely
* Tampering with over the counter horse medicine is trivial compared to a medically controlled injection. Remember the Tylenol scare?
* A bad pill can kill you just as dead as a bad injection.
* The US already has required shots. You have almost certainly received them. Diabetics likely take shots 3 or 4 times a day.
* There is far more actual research on taking covid shots than taking horse medicine. Other than we know horse medicine overdoses are up 250% this year "for some reason".
To those who simply can't get over the political nature of being vaccinated, I ask
Would you serve your kids cat food because Tucker Carlson questioned if the food provided by school meal programs was safe because it came from 'the government'?
because that is essentially what you are doing now if you take livestock medicine rather than be vaccinated.
To those who can't get past the notion of doing something you simply don't want to do, I recommend that you reflect on what the term "Patriot" means at its core.
Is a patriot one who is willing to do something they potentially don't want to do in order to protect the people or is a patriot only someone willing to protect their own interests?
Sometimes I think people in America confuse liberty with anarchy and patriotism with political loyalty. You say that lockdowns and masks are BS. Well, then here is a way to minimize them. Get vaccinated.
I think the FDA sums it up nicely:
"You are not a horse. You are not a cow. Seriously, y'all. Stop it,"
https://www.fda.gov/consumers/consumer-updates/why-you-shoul...
Where do you believe that the average person is getting their over the shelf Ivermectin from?
Do you have an alternate hypothesis for Ivermectin shortages for livestock at feed stores or the sudden increase in calls to poison control and hospitals for Ivermectin overdosing?
Why would the CDC issue a warning specifically about consuming livestock medicine if it was a minor isolated occurrence?
Is there any large scale clinical study (that has not been retracted yet for data manipulation) let's say with more than 1000 participants that clearly shows any benefit to taking Ivermectin for Covid? I'll give you a hint, the answer is no.
The largest double blind placebo controlled experiment for Covid Ivermectin (3,500 people) (https://www.togethertrial.com/trial-specifications) clearly states: Ivermectin : Trial Stopped for futility
What I am opposed to is someone laboring under the misconception that taking Ivermectin is a replacement for being vaccinated, wearing a mask, or taking any real precautions against spreading Covid.
Surely this politically neutral civilian scientist was harassed by the unvaccinated, the kind of people who are why we also need to end online anonymity, as people with "civil liberties" objections are mostly a violent mob, and vaccine passports are really about protecting society from the violence of the uneducated./s
If that bit of sarcasm seems uncharitable, it is for the sake of brevity. We're at the stage where mandates and resistance to them are colliding, and the tactics employed to push through policies that exploit the pandemic are going to include disingenuous agitprop in outlets like the Guardian, and apparently, Nature. The only effective response to that kind of bullshit is truth, and the most effective vessel for truth is humor because it's an honest signal.
I’m not a believer in ivermectin, not non-believer either, but that’s just factually incorrect. It’s not new, it’s been around for ages.
The recent piece in the bbc which “debunked” ivermectin was also a lot of dishonesty and non-science.
As someone who is inclined to think it’s efficacy as a Covid treatment is unproven, what am I to conclude from repeated attempts to dissuade the public and medical establishment from using it, when these attempts are dishonest and built upon lies or rhetorical trickery? The more lies I read which are aimed against ivermectin the more I think it must be effective or why would so many people be lying to say it’s not.
It’s staggering they think the public are so stupid but maybe they’re right. Even Sam Harris, a pretty bright guy, got suckered in by the bbc piece. There was no underlying research, nothing published, not even a preprint. Just the words of a Twitter sleuth who is still in college, but bbc printed it and smart people like Sam Harris jumped on it because it fit their beliefs.
The circumstances are most likely something like this: the danger of the virus is being overhyped, the dangers of the vaccines are being downplayed, the efficacy of repurposed cheap old drugs including ivermectin is being suppressed for the sake of profits.
The result is, healthy young people who almost certainly cannot benefit from taking the vaccine are being pressured to take it, suffering extreme adverse side effects, and being told that they're just psych cases (suffering from anxiety or something similar)
Here's one example of thousands: https://www.youtube.com/watch?v=aebtcTi7EaA Healthy young guy, professional athlete, took the vaccine when there was no need for him to. Now he suffers from excruciating pain, has to flop out of bed in the morning to try to gain mobility, almost passes out when he stands up, etc.
Here's another example, a guy reporting 25,000 comments about adverse reactions in Israel. This used to be on YouTube, but it was censored there. https://odysee.com/@TheInformer:1/avibarak:1
Here's a doctor in California writing to the FDA and CDC about personally seeing far too many adverse reactions for the official numbers to be correct. https://www.sirillp.com/wp-content/uploads/2021/10/Letter-Re...
Slides from a recent presentation on safety signals from VAERS: https://www.skirsch.com/covid/All.pdf
I could go on and on. The point is, people are seeing that things do not add up. The things they're personally seeing and hearing are not matching what they see from the MSM. Nobody likes being lied to. Nobody likes being stonewalled when people are dying. That's where the resentment and anger comes from that fuels the threats. Again, the threats are wrong. But what does any cornered animal eventually do?
That's because they are ridiculous. Side effects from the vaccine are caused by the body's immune response, because the vaccine literally only contains code for the spike protein. Guess what happens when you actually get infected with the live virus? An immune response.
It's about 99.9% likely that the people who had such adverse reactions to the vaccine would have had as bad (or worse!) reactions to being infected with COVID. Not to mention the actual damage caused by the virus!
The basic fact escaping them has turned this into a giant theatrical production in service of political ends....like everything these days.
Then does that mean that the spike protein RNA is itself capable of causing adverse reactions? The J&J vaccine is associated with an increased risk of TTS. If that vaccine "literally only contains code for the spike protein" then what else could cause it?
(the rest of your comment is spot-on, I just don't get what's going on with this specific part)
Here's another reason side effects could happen: https://odysee.com/@breadcrumbs.2.satori:2/Dr-Sucharit-Bhakd... i.e., spike proteins emerging from normally smooth blood cells, protruding out into the vessels, causing clotting. This idea has apparently been vindicated by D-dimer tests.
A whole lot of Americans took the vaccine in a very short time frame. Some people are going to get sick soon after. And of course in every single case, family members will be sure it was caused by the vaccine, because that's how the human brain works.
6.6B doses of vaccine have been given out worldwide. If side-effects like those were at all common it would come out, and they would have come out during the clinical trials.
What do you think of slide 11 from https://www.skirsch.com/covid/All.pdf ? VAERS is known to be vastly underreported. Kirsch calculates using various conservative methods that the underreporting factor for the COVID vaccines may be about 41.
But everyone hates guesswork like that, for good reason. VAERS is undoubtedly very noisy. So what do you think of slide 27 from that same presentation, in which Peter Schirmacher says 30-40% of the 40 people he autopsied died of the vaccine? https://www.sueddeutsche.de/wissen/wissenschaft-heidelberg-c...
All VAERS does is say a person got sick or died after taking a vaccine. It's unverified. It doesn't say if the person was already sick. It doesn't try to ascribe cause. From their own definition: "information on unverified reports of adverse events (illnesses, health problems and/or symptoms) following immunization with US-licensed vaccines." When 200M people get a vaccine, there are going to be some coincidences.
The slide you reference is a perfect example of misuse of VAERS. Of course deaths following (not necessarily because of) vaccinations are going to be higher than previous years when you're vaccinating 200 million people at once, many of them old and sick. Just use common sense. Creating a dramatic chart to compare deaths following vaccinations during a global pandemic and vaccination drive vs. previous normal years is nonsense, and just proves that the author of the slide is an extremely biased source. It's pure emotion-tugging sophistry aimed at a non-expert audience who doesn't understand the data.
Here's an actual source on the safety of the vaccine: https://www.nejm.org/doi/full/10.1056/NEJMoa2110475
VAERS has been completely warped to fit an agenda - often promulgated at the top by snake-oil salesmen who make money from eyeballs or bogus supplements, or by state actors trying to sow discord. https://www.webmd.com/brain/autism/news/20110111/mmr-doctor-...
700k people, 1 in 500, are dead from covid in this country. Even if all 700 of those deaths in VAAERS were from the vaccine, and VAERS was 40x underreported, (which in no way am I conceding either) that's still several orders of magnitude less than the risk from the virus itself. And that's not even considering long covid, another item anti-vaxxers always ignore. https://www.medpagetoday.com/infectiousdisease/covid19/91270
Are other pathologists reporting similar findings? In the article you posted it says they don't agree with him. Why are you picking one voice out of the entire global pathology community to amplify and believe?
Personally I'd rather stick to the overwhelming consensus of the world's top scientists and virologists, and 96% of doctors, on the matter. https://www.ama-assn.org/press-center/press-releases/ama-sur...
If there was really some big coverup involving life and death issues, I have faith a significant enough number of true experts would come forward to make the mainstream media, or even fox news, instead of just a few random sketchy websites.
The above post is the exact reason why we are never getting out of this Pandemic. Just pure misinformation being passed as facts.
Young people can die from COVID but they won't die from COVID vaccine shots. Once they are vaccinated, they are much less likely to spread COVID, which is the real reason we want the young to get vaccinated. So they can stop spreading it.
Individual cases of people having strong reactions to the COVID vaccine is expected and not harmful to the individuals. I fail to understand why anti-vaxxers keep posting this kind of information. They are just telling us what we have already been told we can expect.
Also, if you think having a strong reaction to the COVID vaccine was bad, wait until you get COVID because it just might kill you.
https://www.ibtimes.sg/michigan-teen-dies-sleep-3-days-after...
If we accept that this story is not fabricated, this person was previously healthy. Myocarditis suspected. Slides 62 and 63 of https://www.skirsch.com/covid/All.pdf indicate the vaccines can cause myocarditis, especially in young men. High troponin levels is the alleged indicator, from https://www.nejm.org/doi/full/10.1056/NEJMc2109975
Another victim, aged 18. Clotting suspected, as suggested by Sucharit Bhakdi. https://www.reuters.com/world/europe/italy-halts-astrazeneca...
Another victim, aged 16. Pulmonary embolism. Does this look like a forged/noise report to you (honest question, no snark)? https://pbs.twimg.com/media/E4urslGWEAM_7c3?format=jpg&name=...
Another victim, aged 15. Cardiac failure. https://pbs.twimg.com/media/E0X3XuqXoAAPX2N?format=jpg&name=...
Another victim, aged 13. More heart problems. https://medalerts.org/vaersdb/findfield.php?IDNUMBER=1505250
This is misinformation. The other poster already pointed out how vaccines are linked to myocarditis in young and otherwise healthy people, and a recent study pointed out that this is at least partly is linked to how the vaccines are administered (no aspiration->spike protein injected into blood vessels->heart damage).
Stop claiming that the vaccines cannot be harmful. This only reduces trust in science when evidence of harm mounts, because interventions almost always cause some kind of harm. The question is always how much harm will come from the intervention vs. the probability of getting infected and suffering complications from it. The result of this calculation is not at all obvious, and the widespread push for interventions and damn the consequences is stupid.
The actual numbers seem to be that otherwise healthy teenage boys are more likely to die from the vaccine than from COVID - to be clear, both numbers are very low. Trustworthy stats are hard to come by in any case given that everyone is pushing an agenda.