Regarding catastrophic collision with sharp edge, I think these tires will be susceptible as well. If it's enough of a bump to "bottom out", it's going to dent the rim.
Also, your comment about potholes reminded me of a time that I was driving with a friend and we hit a pothole and got a flat. My friend was driving and looked a the flat front tire and said "I'm glad I have a spare". I look at the flat back tire and said "Unless you have two, we're still going to need assistance."