I think you recognized the contradiction in your own point and corrected it so I will leave it be. It is unimportant to the broader idea of the simulation hypothesis that any individual hypothesis can be disproven. In fact there is an infinite number of trivial variants that can easily be disproven. This is still an infinitessimal fraction of the uncountable space of hypotheses.
Similary it doesn't matter if the claims of any individual religion can be falsified, there is simply another one without those claims. Just because I read something false in one book, or many books, doesn't mean all books are false. Or just because one scientfic paper turns out to not be replicable doesn't mean empiricism is fundementally useless.