I'm the co-founder of TechiesGiveBack (techiesgiveback.org). We are aimed at helping the NY tech community give back to charity. We've considered different ways for how to approach this problem. I've also been approached or spoken to a variety of different companies looking to make a difference - Crowdrise, IndieGoGo (which we used for a recent fundraising campaign), Let's Give, and others.
Just spoke to Gabriel Weinberg about his open source tithing effort this morning (http://www.gabrielweinberg.com/blog/2010/11/help-me-start-a-...).
We are working on our own new initiative which will allow mature startups and tech companies to let their employees donate a little bit of their paycheck to charity. I'd be happy to talk about that over email...
(We don't take any money for ourselves - we do it pro bono and all work in tech. We raise money for other charities).