Suicides among Swedish men decreased after Viagra became more affordable

correct

I tried both and get headaches from both. So I'd prefer a 4h headache vs a 24 hour headache

There is only weak evidence it increases sildenafil half life -I shouldn‘t have mentioned it.

Are you asking about amateur or profesional sports? I competed in amateur mountain bike races for a number of years, but I never took any medication to improve performance and I see no point in doing that. As an amateur, going to competitions every couple of weeks and getting in the top quarter was the purpose, not winning it; it was a strong enough motivator to do sport - the atmosphere, the tracks and the views in the forests were a great reward.

For profesional level, medics can tell what is allowed and what is not. I am not a doctor, but most performance-improving drugs are forbidden.

What kind of performance?

We always got our all star creatine.

I didn‘t notice any changes in workout performance from tadalafil or l-citrulline and I consumed insane amounts of them.

I use it for bodybuilding. Helps with the pump. It's in a lot of pre-workouts.

Oh wow, I thought I was the only one who had that exact reaction. Very strange feeling, like a thousand warm caterpillars walking over your skin.

It was enough for me to stop using it (though I don't think I ever really saw any benefit, so it's not like the choice was hard).

Drugs that lower testosterone will typically accomplish that outcome. Men that go through prostate cancer treatment for example will often have erectile dysfunction (due to hormone therapy targeting testosterone - androgen deprivation therapy).

SSRIs tend to reduce libido. That’s not exactly the same thing, but they are connected.

There is a widely circulated rumor that in the Romanian army they used to put a small quantity of bromide (sodium or potassium? don't know) in the evening tea; it is not supposed to prevent an erection, but total lack of sexual desire. This was 30-40 years ago, I was not able to find any official documents related to that, but any men over 50 years old is telling that story.

So many come to mind, I could write a whole article about it.

None of them have an acceptable side effect profile, many of them can potentially cause persistent inability to have sex to the point where not even megadoses of pde5 inhibitors help.

I strongly advise against ever taking SSRI or 5ari for this purpose. They are now known to cause persistent ED in susceptible individuals.

HRT

Great way to get PM's from girls :)

If your issue is Sleep Related Painful Erections (SRPE), then Baclofen works well.

Anti-androgens and GnRH agonists like Spironolactone, Cyproterone Acetate, Goserelin Acetate, Bicalutamide to name a few. Also to a lesser extent 5α-reductase inhibitors like finasteride (Propecia) which only suppress the more potent dihydrotestosterone.

All of these work by suppressing androgen production (mostly testosterone and dihydrotestosterone), this will suppress most of the male libido. While they don't remove the ability to get an erection if you try, they will prevent the hormonal lead-up that would normally lead to one. You'll likely stop thinking about sex entirely, there won't be much of a drive. GnRH agonists like Goserelin Acetate (zolodex) are highly effective, spironolactone is very weak and a potent diuretic.

On the downside... an adult human body expects to have a dominant sex hormone, either testosterone or oestrogen, and a lot of things hang off this. For one, initial breast growth is inhibited by testosterone, so you will likely develop gynecomastia (unwanted breast development). Your body hair will reduce, though facial hair is mostly unaffected, and your skin will become softer. Long term you are at increased risk of developing osteoporosis, and your testes and genitals will shrink. Sperm count and viability will reduce, though for some people this is recoverable.

It will halt any male pattern baldness though.

Most of these drugs are used for treatment of prostate and testicular cancer, so their effects are well known.

For the interested: You can prevent ejaculation (i.e. there is a loss of seminal emission, but not orgasm) using silodosin. It can be used as a male contraceptive. Low doses tend to work, but I recommend testing it before the real action[1]. You will still have orgasm, but without ejaculation. Be cautious though, because it is not without side-effects. Do your research!

It is funny how there is not much of a mention of this substance for this purpose, even though it is indeed effective for it. A male contraceptive pill.

[1] Do not forget about the importance of dose, onset of action, duration of action, stomach content, and so forth.

Pre-load 5-HTP for a week

Yes! I wish this was known. Mine lasted a couple of days. Thought I'd never feel joy again.

I once accidentally took about 500mg (tested). Felt depressed for weeks. Everything felt wrong on my skin. It gave me an understanding of what it means to be depressed. Few weeks later I was fine again. But definitely a scary experience. I began to hallucinate parts of conversations. Then the muscles (?) In my ear started to feel really painful. Then I realised I had actually taken too much

Well you need to educate people for sure..

You really need to abuse for a super long time some lsd to be messed up. I know a wide bunch of people in the party scene who absolutely abuse MDMA but they dont have more mental illness than the avetage smoker

It’s definitely theoretically possible but having been pretty involved in the scene I’ve only ever seen LSD, shrooms, and other classic psychs bring out psychosis/schizophrenia in people who were probably going to develop it anyway (or at least were pre disposed). This was around college age when schizophrenia usually emerges. In general they don’t seem to cause mental illness in people who weren’t already pre disposed. (Obviously this does not mean psychs should not be treated with enormous respect)

I’ve seen a lot of people get low-grade cognitive dysfunction from mdma abuse (neurotoxicity due to “doing it wrong” ie overheating/overdosing), and while not in the class of drugs we’ve been discussing I’ve seen xanax ruin more lives than any other drug by far

Well, internet use -> computer use -> better economics + indoors more often.

Contrived but not ridiculous

I don't agree with this paper's statistical analysis, and I think there's probably a different trigger for the change BUT I came here to say that I strongly agree with you that the paper has to be taken on its specific merits. It's perfectly possible to have good epidemiology based on time series data.

(I feel like I should cite something. It's been a long time since I was a professional epidemiologist and I'm way too lazy to look up anything recent, but Oli Miettinen's book "Theoretical Epidemiology" is an example of how some epidemiologists are very clever and very careful.)

I guess it's the increased blood flow to the head. Same reason the porn industry aren't huge fans of Viagra - it tends to make the face red.

from a quick glance it seems PDE5 are mostly part of the cardiovascular system metabolism, I was more wondering about direct neurological effects.