I had to do a second-factor authentication with my bank not too long ago. I had written a cheque for an unusual purchase; they called me and said "there was an issue with the signature check on a cheque you wrote" so I logged in, verified my identity and approved it manually.
I assume that they only checked the signature because the payment was outside of my normal habits, because my signature is an inconsistent mess in the best of times (I sign about 10 cheques/year because reasons).
The worst case for me is the stylus pads at checkouts. I can barely use those coherently when I'm not under pressure, so when there are people behind me in line and a cashier waiting for me to leave, the social anxiety kicks in and I get a pair of initials and some extra lines, at best.