FWIW I use my Windows 10 Pro (VLK) license on my gaming PC, and as a virtual machine when using Linux. It's undergone 3 activations, initially for the desktop, once when I was using VirtualBox and the last when I converted my VDI to VMDK when I migrated to VMware. All activations were several months apart however.

Windows activation servers were happy enough with that, without any install becoming unactivated (other than the VirtualBox to VMware conversion which is the 3rd activation).

While you can use Windows unactivated but it restricts access to various settings, which may not be important to you depending on your use case.