The author seems confused about how BK channels relate to tolerance, here he notes that decreased BK channels lead to increased tolerance: "Exposure to alcohol upregulates microRNA (mir-9), which in turn modifies BK mRNA, selectively destabilizing certain types of BK mRNA."

Then later he seems to be stating that decreased BK channels would lead to decreased tolerance: "The consequence of this would then be that the development of alcohol tolerance could be slowed or halted by preventing the modification of BK channels, like by using RNAi to degrade certain types of BK mRNA."

Perhaps he meant "by using RNAi to degrade mir-9". Ignoring the above issues, it seems very hand wavy to say "let's just get this RNA interfering drug into your brain and target this specific BK RNA".