What do you think it means, when people want high fixed salary and not stock options?
I work for a non-startup in the NFP sector, we've hired a lot of Indian heritage labour, they're great. But, so are people from under the sea, Mars, Africa. I don't care where you come from if you have the chops. It's a mistake to assume all Russian graduates are maths wizards, All Chinese are spies, All Indian degrees come from a degree-mill. "it depends"
Hiring remote early stage of anything is a huge risk. bandwidth to communicate isn't as good as f2f but you can re-cast this as "be highly specific what you want from remote workers" -There is also a time compression effect of their work hours being offset from yours, for some people. It can be really beneficial in hours-to-complete terms, but .. communication long line sucks.
(I should be clear your questions were read as implicitly devaluing labour from India. If you didn't mean that, I apologize)