I work in industrial biotech, read the entire article and found it mostly compelling, aside from lacking discussion of the reasons meat production might increase in cost over the time frame of the analysis.

The fundamental challenge is not a lack of understanding - it seems to be mostly centered around keeping bacteria out of giant 100,000 Liter vats, and out of all of the smaller upstream processes.

Think of biotech as happening in successively larger tanks. Start in a vial, go up to a flask, go up to a tank fermenter, go up to a bigger and bigger vat. If competing bacteria get into your process at any of these steps or the transfers between them and start winning, you kill the batch and start over. And you probably take down your equipment for a deep clean as well. This takes you offline for some time. This is already a problem for fermentation of other bacterial cultures, but it’s an even bigger problem for animal cells because they grow so much slower. So there’s some lack of fundamental understanding on animal cell growth mechanisms.

Given how much attention has been focused during the pandemic on understanding how to limit the spread of germs, it seems to me that there may be some synergistic advancements in keeping large scale processes contamination-free. A lot of it is human factors.. operators using proper PPE etc. Now we have a global population that understands all of that better.. maybe that moves the baseline.