You need energy mastery. Ability to harness infinite or practically infinite energy available freely. With this understanding and power you can innovate further, perhaps gaining the ability to create matter and one day transport it along the fabric of space outside the constraints of existing matter (time).
Then again, maybe true advancement means losing interest in manipulating matter, turning inward and finding or developing enhanced mental states that let us see things clearly without understanding everything empirically.
Perhaps the ultimate goal is to be at peace and even joyful at living and dying. Humans are still very believe-y, angry, outward and confused.