The eventual linchpin is roundtrip latency. If you want to have a frontend with native level responsiveness, you simply can not move all logic to the sever. Physics will get in your way.

So any universal solution will have to include strong client side prediction in addition to handling the server (something the game industry has understood and implemented for years, and I remain confused as to why it has gained near 0 traction on the web).

To my knowledge Meteor is still the only frameworks to explore down this path, but it has never really caught on. Does anyone know of any frameworks that acknowledge this issue and manage both server and client side accordingly?