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There are long-acting (e.g. 8 weeks) injectable versions that are outperforming[1] the daily pill so that approach shows some promise. Not that anybody enjoys injections…

[1] https://www.hiv.gov/blog/long-acting-injectable-form-hiv-pre...

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Once every 8 weeks is entirely more palatable and manageable than a daily pill in my mind. Daily pill forgetfulness leads to things like unplanned kids. Unplanned kids are life altering, but generally not deadly, unlike a communicable disease like HIV.

I don't want to downplay the severity of contracting a life-altering disease like HIV, but with modern antiretroviral therapy the life expectancy for HIV positive people is actually about 70-80 years, though not that ART is side effect free...

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