This is a pretty wild concept, not that I disagree with it.
But when you think about it, we're asking a tool originally designed to browse documents on the web, to now execute what is essentially a (safe) binary application, and not to let it connect to the internet, while inside a document in a web browser.
I can't see how the future of the desktop is not going to be radically shaped by WASM, in whatever form that takes.