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Comment by Cthulhu_ | Hacker News Reader

Citation needed; I know research into psychedelics is difficult due to restrictions, but anecdotal evidence is not enough to start recommending it without listing the necessary caveats.

I mean "Ivermectin has been shown to significantly help with Covid" has the same weight to it, and I'd never recommend anyone take horse dewormer. Maybe if they had worms and it was the only thing available.

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> research into psychedelics is difficult due to restrictions, but anecdotal evidence is not enough to start recommending it

Eh? Lions Mane doesn't have any psychedelic or psychoactive effects.

Lions mane isn't psychedelic, but it's noticably psychoactive. Similar to caffeine in effect, intensity and duration without the jitters or sleep disturbance.

I've never heard of it having any stimulating effects; indeed, I've heard it can be helpful with sleep. Are you able to point to supporting information?

In my last comment I was speaking from experience too - I tried taking it for 3 months, and never noticed any effects whatsoever.

Horse dewormer is just one way Ivermectin is used, just like ketamine is a horse tranquilizer, but has other uses. Not advocating people take it or buy horse dewormer to get it, but you shouldn't call it that generally.

Calling it horse dewormer is probably somewhat salient if you're taking the horse sized portion, rather than the human sized portion, however.

Sure, but that's been shown to be largely a media creation, and not what's actually happening...

(standard disclaimer - not using/promoting Ivermectin, just not a fan of media distortion)

Ivermectin is an FDA approved drug and is regularly prescribed to humans. Sure, it probably doesn't do anything for covid but it's not just 'horse dewormer'.

You can remove the "probably". The manufacturer of Ivermectin states there is no scientific evidence [0] supporting the use of the drug for COVID-19. So much for the notion some espouse that "Big Pharma" pushes their drugs on us without fail.

[0] https://www.merck.com/news/merck-statement-on-ivermectin-use...

It is out of patent

Just to throw this out there. https://c19ivermectin.com/

It's a pity that the whole issue has become politicized, but that's modern times for you. That's why ivermectin is called 'horse dewormer' rather than simply a medicine for parasite infections with a number of human applications. It's a term like 'XXXX denier' which is used to tie a political adversary to concentration camps by playing on our disgust or fears.

Does it do anything for COVID? Dunno. Should it be a discussable matter without internet censorship and crazy people twitterstorms? Maybe. Am I sick of being propagandized by everyone? Yes.

If you're so certain that ivermectin doesn't do anything for COVID-19 then you ought to let the NIH know. They're currently running a huge clinical trial on it.

https://www.nih.gov/research-training/medical-research-initi...

You might also want to let these researchers know that you disagree with their results

https://www.mdpi.com/1999-4915/13/6/989

I can’t edit the comment, but this provides some more detail on Lions Mane. Also note that it is not a psychedelic mushroom.

“ The evidence so far has shown that H. erinaceus mycelium enriched with its active compounds is capable of delaying neuronal cell death in rats with neurodegenerative diseases, such as ischemic stroke, Parkinson's disease, Alzheimer's disease, and depression. Moreover, results have indicated that administration of H. erinaceus mycelia enriched with its active compounds can promote functional recovery and enhance nerve regeneration in rats with neuropathic pain or presbycusis. Despite that more clinical research is needed to fully understand the potential applications of erinacine-enriched Hericium erinaceus mycelium, the majority of preclinical data strongly suggests that it is safe and offers much-needed neuroprotective applications.”

Source: Neurohealth Properties of Hericium erinaceus Mycelia Enriched with Erinacines

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5987239/

Lion's Mane mushrooms are not psychedelics though

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