The only issue I've run into is that for some apps (Zoom, Firefox, Chrome) which are set to use my "default audio device" for input or output, it selects the correct device initially, but if I change the default/system device (via gnome sound settings) later while it's in use, most (all?) of the time, the application continues using whatever device was selected initially.
I haven't bothered to debug or see if this is a known issue as it hasn't bothered me much since most apps allow switching to explicit input/output devices which works fine. I believe (but haven't definitively confirmed) that changes via pavucontrol also work, so perhaps it's something with the gnome sound settings?
Anyway, huge thanks to the devs who put their time, effort, experience, and talent into making PipeWire happen. It's a huge step forward on multiple fronts