Second, lighting is a careful balance, but in general, the simpler the rig, the better. Pull an IBL HDR map from somewhere, use a single directional light, and let the bounce lighting do the main work here. Outdoors looks gorgeous and that's a single directional light, and a ton of bounce. And that's the same thing providing the light in this room scene as well.
Third, learn the tricks and technologies. Learn about lightmapping, about shadow mapping, about the different shader tricks, about why real-time transparency is hard. Yes, libraries like Three.JS can abstract over some of this, but some fundamentals in the tech can help you focus on the things that will work, and the things that don't. Simon Schreibt has some excellent guides and tutorials that are artist-focused about tech art.
The lightning here isn't realtime: just a bunch of baked lightmaps fading in and out. Not even SH probes!