Every time I traveled, we had to have "our shots."
These were 100% mandated by the country we were coming to. Since my "home base" was in Africa, we had some fun bugs, and I had to get a whole battery of shots.
I have several vaccination scars on my body, and I developed a lifelong fear of needles, as a result of the giant horse needles they used for the thick sludge they'd jab me with (which left me feeling like I'd lost a fistfight with a gorilla).
When I got my COVID vaccination shots, I didn't even feel it, as the needle was so tiny.
Historically, mandated vaccines weren't mandated before we knew they were safe longer-term. We're still awaiting FDA approval for a majority of the available SARS-CoV-2 vaccines in the US, yet many folks would be mandated to receive one.
Many folks will see this as being mandated to be a test subject, which is why there has been substantial legal pushback against the mandate less than 24 hours after Biden announced it.