You have to remember the audience is a college of music. In a venue like this, the primary question is not how to become a commercial success, it's how to become better at your craft as a musician.

Mayer is also speaking from the unique perspective of being a serious commercial success, wanting to nurture it, but still having the "burden" of creating music to (his) high standards. I don't think most normal people need to create such a black and white line between posting on Twitter and writing a song, but Mayer needs to, and it's at least somewhat interesting to hear his reasons.