Anyone in the know got some ideas about the advantages of DNA vaccines vs mRNA? What I gathered so far is:

a) Easier handling and stability (DNA is just inherently more stable than RNA)

b) Potentially easier to manufacture if you make an un-encapsulated plasmid vaccine (though I have no idea how that effects effectiveness)

c) Higher payoff per material?? I assume that you can get more protein created per ng of genetic material.

Does anyone know if DNA vaccines generate protein over longer timescales than mRNA? I assume that once the plasmid is picked up in the nucleus it becomes pretty stable until the cell itself dies - mRNA should be cleaned up relatively more quickly?