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Comment by endisneigh | Hacker News Reader

wow, wasn't aware of this development. which COVID vaccine is this? is it one of the nasal ones?

I think they're saying that other vaccines, not COVID vaccines, have this property. We can't assess decadal resistance yet for COVID vaccines.

If so, I'm not sure how that's relevant to COVID at the present. Per the article we're discussing it's unclear how long a 3rd dose will be effective for, hence my comment to begin with.

If we were to pre-suppose you gain a decade of prevention then yeah, that'd be great.

We don't know how the protections in the current vaccines are going to play out until we investigate them more.

Agreed, but we already know how 2-dose plays out with respect to Delta. The article in question is investigating how a 3rd dose fares against delta. There are also delta-specific boosters coming out soon.

I think they're saying that we can hope that three shots gives long term resistance, as it happens for other vaccines. We can only hope, and it's not a totally unrealistic hope given how other vaccines work.

What are these other vaccines? are the vaccinations for other coronaviruses? I'm not a biologist so I'm not seeing the connection. Is there reason to believe adding more doses would make the prevention jump from less than a year to a decade?

You can see the recommended vaccine schedule here. Several include 3+ doses.

https://www.cdc.gov/vaccines/schedules/hcp/imz/child-adolesc...

I'm aware of the 3 dose vaccines - what I'm asking is if there's any connection between the duration and the type of vaccine and the type of underlying virus.

The flu, for example as existed longer than COVID and we do not have a "3 dose" vaccine that prevents the flu for a decade. Why would we expect this for COVID as opposed to an annual booster?

HPV is a 3-dose vaccination in most cases. I believe Hep A and Hep B vaccines also have 3-dose versions, but I'm not sure if the 2 or 3 dose schedule is standard.

I assume this is snark, but misguided if so. I believe the parent comment was simply stating there are some vaccines generally with this trait, so perhaps the covid vaccines would similarly improve from a 3rd dose

it was an honest question. what about it came across as snarky?

Expecting that we would be aware of vaccines that provide a decade long protection against a disease that has been around for less than 3 years. I mean we could have those vaccines already, but we couldn't possibly know that we have them until they've been around for a decade or more.

Per the article we already know 3-dose of Pfizer does not offer a decade of prevention. What the article states is that it offers a level of protection similar to when one first completes the two-dose regimen, so we don't have to wait a decade to know.

All we know is that an additional dose does increase your protection, but it doesn't necessarily give you a decade of protection since there were people who got the 3rd dose and still got COVID.

> All we know is that an additional dose does increase your protection, but it doesn't necessarily give you a decade of protection since there were people who got the 3rd dose and still got COVID.

That doesn't mean anything regarding protection longevity. There will always be instances of individuals who fail to receive immune protection from a vaccine. The vast majority of people could potentially receive years of protection with a 3rd dose, while a small group doesn't get any protection at all. That isn't specific to covid.

Sure, but if you like at the data in the article it's virtually identical to the 2nd dose data.

this wouldn't be covid-19 vaccine, rather a vaccine for another disease. We absolutely do not have any data on the efficacy of any covid-19 vaccine after a decade (or more than 18 months or so) yet.

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