Should the data be collected without consent by exposing the public to it for decades or provided by clinical trials funded by the company that wants to bring it to market?
If any effects are unmeasurable with standard clinical trial practices, then it's safe. People care about things that actually are harmful.
> Proving a negative ("this is not dangerous") is hard :)
Which is why I never asked for it. Safety standards are always phrased positively. OSHA doesn't say "workplaces must not be dangerous", they say "wear a hard hat, the employer shall do ___, employees must not be forced to do ___". It's very easy to regulate that "new compounds must be shown not to affect human hormone levels at X concentration, must be shown not to be carcinogenic in Y model of cancer" etc.