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Comment by dredmorbius | Hacker News Reader

This is a ... typically clickbaity ... university press office account of a paper:

"Small RNAs are modified with N-glycans and displayed on the surface of living cells" by Ryan A. Flynn, Kayvon Pedram, et al.

https://www.cell.com/cell/fulltext/S0092-8674(21)00503-1

https://doi.org/10.1016/j.cell.2021.04.023

Given the Sci-Hub moratorium on new uploads[1] , this is not publicly availble.

________________________________

Notes:

1. See: https://www.livelaw.in/pdf_upload/pdf_upload-386427.pdf (pdf) https://news.ycombinator.com/item?id=25550058

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thanks. i should have linked to the paper and highlighted key points in the comments.

i’ll do this next time.

the goal was to stimulate discussion on two points:

1) scientists discovering a fundamental biomolecule in 2021 is astounding and proves how opaque human physiology remains; how can we accelerate science and deepen our understanding? (putting papers like this in the public domain is step one.)

2) what are good research questions for probing the potential link between glycoRNA and disease?

I don't know about "astounding" and "remains opaque". From classes I actually already (mis)assumed that rna had glycans, because almost every single thing your body produces has glycans put on it, and glycoscience is a pretty established bio subfield it seems. The surprising thing to me isn't that glycans are on rna but that researchers hadn't checked, if this groups is the first to.

hahaha, I thought the same thing? "We didn't know glycornas existed yet? seems like it would be obvious that they would..."

Ok, we've changed the title to the first part of the subtitle.

thanks dang!

https://www.biorxiv.org/content/biorxiv/early/2019/09/30/787...

I'm presuming this is a preprint.

(Not able to read a PDF right at this moment. Contextualising naked links is helpful.)

HTML version: https://webcache.googleusercontent.com/search?q=cache:https:...

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