The right comparison is an airplane not a semi-truck. If you can drive a semi somewhere it doesn't seem like this makes much sense.
It carries substantially less (it looks like ~1/4 the mass), but it looks like you can buy more than 4 of these for the cost of 1 Cessna Caravan (wikipedia quotes a few million dollars for one of those, and the quote in this thread is a few hundred thousand dollars for an airship). You need 0 pilots to move those 4 around instead of 1 to fly the airplane, and the claim seems to be that it's more fuel efficient per kilogram-meter so those 4 should take less fuel too. Moreover you're getting increased flexibility because if you only need a fraction of the weight, you don't need to send all 4. You also get vtol take-off and landing with the airships.