"seal" does -- whether any group is collectively capable of taking chain-of-exposure and its management seriously.
Make your island arbitrarily small and remote but have even a single person who's boating/flying or any kind of unmanaged travel outside the bubble regularly and you'll see infection overrun the island.
Pick an arbitrarily large city within miles of another on a shared continent with an unmanaged pandemic. Have it populated with people who are unified in careful contact management and they'll keep outbreaks scarce and small.