> Conclusions:
Moderate-certainty evidence finds that large reductions in COVID-19 deaths are possible using ivermectin. Using ivermectin early in the clinical course may reduce numbers progressing to severe disease. The apparent safety and low cost suggest that ivermectin is likely to have a significant impact on the SARS-CoV-2 pandemic globally.
The original title of Ivermectin for Prevention and Treatment of COVID-19 Infection: "A Systematic Review, Meta-analysis, and Trial Sequential Analysis to Inform Clinical Guidelines" was too long so I modified it to fit on HN.