Former top officials seem to have a nose for this. [1]

> Former acting Comptroller of the Currency Brian Brooks has resigned as the CEO of Binance U.S. after just over three months. He cited “differences over strategic direction.” Meanwhile, Binance is facing regulatory scrutiny worldwide, including in the U.K., Malaysia, Japan, Cayman Islands, Hong Kong, Thailand, Germany, and Lithuania. [editors note: that list has since grown]

> And only really relevant to those that are reliant upon nakamoto consensus…

Regarding speed and efficiency, yes, they principally apply to PoW coins.

[1] https://news.bitcoin.com/binance-us-ceo-steps-down-crypto-ex...