Chronic isolation massively accelerated the burnout I had from my startup. While I had worked from home for several years, I went out most nights of the week to see friends. The lockdown eliminated that.
I had to make a serious change in direction for my own mental health. So earlier this year I put the startup on indefinite hold and did the unthinkable: I got a job.
I feel tons better now than I did a year ago. I still prefer working from home, but now I have people I can talk to on a daily basis.