- deuterium-tritium fusion, which produces lots of high-energy neutrons
- the neutrons help to keep the plasma hot, but being neutral, they escape the magnetic bottle; there is a lithium blanket around the reactor to catch them
- the neutrons that hit the lithium produce tritium for the reactor, and steam for the turbines
"Dense Plasma Focus device with aneutronic hydrogen-boron (pB11) fuel"
Different types of engines have different details of where that energy gets lost, but ultimately they are devices that if left to run indefinitely would equilibrate in some way and the way that they idle tells you a fair bit about where the energy flows are.
Turbines are pretty impressively efficient, but something can always be better. They often utilize the low grade waste heat in steam heating though, so a lot of times the efficiency is extremely good when you include free heating or process heat (in a plant they might use that steam to heat another piece of equipment).
It hits the sweet spot on fiscal, engineering, safety, and science fronts. Energy extraction is very challenging, we're likely hundreds of years away from aneutronic fusion, for example. The research area you are asking about is direct energy conversion, of which aneutronic fusion is one small branch (though within it, there are many scientific and engineering branches to explore).
We're only a bit over a hundred years from developing quantum mechanics and relativity, how can we possibly say anything about hundreds of years from now?
If something is well enough understood to accurately predict the timeline, we could do it much sooner.
If we have no idea how to do something, then "hundreds of years" means nothing, except maybe "not proven impossible yet".