But most of them are easy to spot, at least in the aftermath. If you spayed over a sign, people would notice. If you removed one, a driver would probably not be able to directly notice, but he might notice the situation (i.e. you should not go fast in front of a school, even when the sign is missing) or you could find evidence if an accident happens.
The scary thing about these signs is that they could easily go unnoticed, especially if placed well (for example a crossroad with already sun-bleached signs). Neither a driver (who could possibly intervene) or an investigator would be able to spot this, unless they're specifically looking for it exactly.
Things like this are, in my opinion, also exactly why people put the bar of trust so high for autonomous vehicles: They might fail in ways totally opaque to us. You can at least somewhat estimate what a person might do [0]; for autonomous cars, this is hard or even impossible.
[0] I know someone could be extremely drunk or on drugs and possibly also mistake a stop sign like this, but you'd usually see some warning signs. An autonomous car might go from totally normal to batshit insane without any prior indication or apparent reason.