The difference in pay between W2 and 1099 was $30,000 / year. This more than covered all taxes and health insurance costs. (And even the W2 rate was much higher than typical full-time salaries.)
The main difference in taxes is the 15.3% you pay towards FICA, where an employer has to cover most of it for W-2 (you still pay 6.2%.) I don't remember all the exact numbers any more, but if 1099 is ~25% more than W-2, odds are pretty good you can do better on your own, especially if you take advantage of the solo 401(k) to reduce your tax load.