Thanks for the feedback! I'm happy to share more.
- They're derived from secondary lymphoid tissue. We're trying to biobank as broadly as we can to capture sex, age, race, HLA, genetics, and other characteristics in a wide net.
- These are not iPSC-derived organoids.
- This depends on the readout but workup post treatment so far has included histology, immunofluorescence, serology (ELISA, SPR, etc.), CyTOF and other flow, broad RNA-seq, bulk and single cell repertoire sequencing for B and T cells, and MSD/Luminex.
- We haven't looked for mutations from drug and vaccine treatment. We'd love to know more about what you're thinking there.