MathML is the only accessible option. Screen readers work with it.

Tools like KaTeX output both HTML and MathML simultaneously (HTML for rendering, MathML for screen readers), leading to massive page bloat. MathJax requires client-side JS to look good, which is a big 'no' for me.

Right now, there is no way to display math on the web that: (1) is accessible, (2) works across all modern browsers, (3) is not slow or bloated in some way. MathML in Chrome fixes basically all these problems.