Are they that different? I thought the major difference was that the disaccharide in cane sugar was split in corn syrup, which happens very quickly in your digestion anyway.
It has significantly more fructose which can cause digestive issues for some people (search fructose malabsorption, it's apparently fairly common).
https://www.youtube.com/watch?v=dBnniua6-oM - the main gist of it is cane sugar is 50/50 sucrose and fructose while HFCS contains much more fructose which is harder for the body to digest/make use of as it requires being broke down or something and its hard on the liver ect. that video goes way into depth about it if your interested.