It is literally burning electricity (oil, coal, Fukushima) for no real reason (MS wants to patent computational heating?)
We have no clue how proteins work/interact (this is why epigenetics is hyped these days). We have some "educated guess", but it is mostly data harvesting from public databases and then doing some simple Bayes or correlation analysis, without much scrutiny on the harvested data itself (ie. was it made up using multiple imputation?)