Depends what you're looking to do - if you really value your privacy, yes, you're going to have to give up some convenience, but I can assure you, it's really not that bad if you put in a little work on an occasional basis, it's not the constant maintenance nightmare that some people seem to expect.

I fired up Syncthing on my phone and NAS and restic to perform encrypted backups nightly to B2, sure, you're not going to get some magical cloud image recognition stuff, but do you really need or even want it?

Everything can integrate quite nicely, but plan to do the connecting work yourself as a one-off with some occasional maintenance a few times a year.