The number of insects have dropped dramatically and that has impacts on the entire food chain. Particularly, the ability for plants to reproduce. The pesticides themselves also make it all the way up the food chain.
Neonicotinoids have a half life of 5 years and we spray fields EVERY YEAR. So it’s building up in the supply chain. I live surrounded by corn fields and I basically only see wasps, Japanese beetles and some ants. Growing up we saw a ton of different insect species and numbers.
Finally, all these chemicals interact and frankly we have no idea of the long term impacts when combined.