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chana_masala

> This is probably the most scrutinized vaccine ever

Not in terms of long term data, at all

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What exactly are you expecting to happen, for the vaccine to turn around and kill 600,000 Americans?

Over a long period of time anything is possible.

Isn’t this just an argument for nihilism? Over a long time anything is possible, but that’s not an excuse to ignore the data that we have right here and now. Never mind that there will never be a point where there isn’t a “long period of time” in front of us, which becomes a convenient excuse for permanent inaction.

Also, anything being possible is not the same as anything being probable. The vaccine might make me grow a third arm too, after all anything is possible in the long run, but you would laugh if I said that I wasn’t getting a vaccine for the fear of my tailoring bill.

On websites where covid vax hesitancy is rampant, I often see posts discussing antibody mediated enhancement, vascular damage caused by circulating spike protein increasing vascular damage and causing death from heart attack and stroke in a few years, prion disease development from misfolded protein propagation, and fertility issues. For most of these issues, long term data is needed to rule them out.

See these peer-reviewed papers for some insight into the second and third order evolutionary dynamics that we face with the current spike protein focused mRNA vaccines for SARS-CoV-2 [1][2].

These are serious long-term concerns, which may not manifest overnight, but they are certainly on the radar of many experts in the field.

[1] Risk of rapid evolutionary escape from biomedical interventions targeting SARS-CoV-2 spike protein https://pubmed.ncbi.nlm.nih.gov/33909660/

[2] SARS-CoV-2 immune evasion by the B.1.427/B.1.429 variant of concern https://science.sciencemag.org/content/early/2021/06/30/scie...

[3] Imperfect Vaccination Can Enhance the Transmission of Highly Virulent Pathogens https://journals.plos.org/plosbiology/article?id=10.1371%2Fj...

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