You can't build the battery-changing system into the drone due to size, power, and weight constraints, so it has to be part of the van. So you need something on the van that can
1) Secure the drone in place while the battery is being changed, and ensure drone can successfully land with sufficient precision for the battery changer to work, or to manoeuvre the drone into place.
Probably you would also want to keep supplying auxiliary power to the drone so you don't have to wait for it to reboot and reconnect to the van's swarm management when the battery is removed.
2) Physically remove and replace the battery, including manipulation of any connectors and fasteners required.
3) Convey batteries between the drone and the storage inside the van. I imagine this would work something like an LTO tape library, where the van tracks which storage slots are occupied, if they've been used or not, and have some internal mechanism which moves batteries between the storage slots and the battery changing mechanism.
I can see this being quite bulky, as with that many batteries you would need compartmentalisation and maybe even a miniature fire-suppression system in case one of the batteries "cooks off".
4) Must not interfere with whatever cargo-loading system is in place - you could have a nice flat battery tray in the roof, but you might need to punch a hole through it to fit a cargo elevator or so on.
Also, must not take up too much internal volume of the van that could be better used for profitable activities (storing cargo for delivery)
5) It would still have to comply with normal road requirements such as maximum heights, environmental resistance (rain, dust, etc.) and so on.
That's just off the top of my head, I'm not an engineer and I'm sure there are plenty more challenges that I haven't thought of.