I changed an ex-girlfriends life with Reader -- I swear to god. She's a (semi) extreme couponer and deal hunter. Every day there's dozens of give-away's. Good, expensive stuff. Be the first 100 to click on this link, or the first 25 to take that survey, etc. She followed a dozen+ blogs every day to stay current on these things.
When I set her up in Reader and she discovered the "Next Item" button, it changed her life. It was really pretty great to be able to help her like that and see her eyes light up.