I'm at best doubtful about life on Mars because I find it hard to imagine some form of life that occupies a small part of Mars i.e. it's only in the parts we haven't seen. I tend to think if there's any life on Mars it'll find a way to deal with the conditions on all of Mars. By the same token if there's any silicon based life then it'll pop up in places that we can find as well as those we can't. Maybe it does best in places we can't but surely there would be some oddball silicon based creature that would beat the odds.
The macro example would be the extinction of the South American marsupials when the North and South American land masses merged. All the placental animals in North America went south and all the marsupials in South America went extinct. Except for Opossums which for whatever weird reasons not only survived but went into North America.