You seem to have written a glorious series of interlocking hacks which yields a small, tight, simple, fast, portable, useful nugget of functionality in a single file. Bravo.
I really like it and will attempt to use it for something real. However, I fear that even this bit of magic doesn't address the central problem of our time, which is software distribution. I believe that the web has solved that problem, and although the web is currently abused by central power, and webapps tend to be thin, animated protocol viewers, it doesn't have to be that way. You've created/discovered a local (maybe global, given real-world limits) minima of what a binary executable can be, but this only finds the minima of the pain of traditional software distribution, but doesn't eliminate it.
The real path forward, if I might be so bold, is to make a browser on top of cosmopolitan/redbean, and bring TBL's original dream of a singular client+server http/html runtime to modern fruition - but with additional superpowers that cosmo brings which I don't think TBL anticipated. No doubt some enterprising souls are already working to get Bellard's QuickJS into redbean to mimic node. Then you need window/drawing context, and the rest of the browser, including layout, could be done in (presumably equally tight) JS. Have you given any thought to exposing those drawing syscalls directly instead of delegating to the browser? And if you haven't and are interested, may I suggest Java's AWT v. SWT as an interesting case study in "where the indirection should go".