There is a very real possibility that allowing 100% remote work could very well prevent them from being "trailblazing engines of innovation". So many things start as adhoc idea's from a random discussion that would never have happened without being in the same location.
Work has gotten easier in this remote world as it turned my whole team into input / output engines with very little thought along the way but god it's sucked all the creativity out of our work and removed most of the critical review of any product decision.
Coming up with projects that are impactful and novel is a large part of our jobs, and creative velocity has nose-dived since everyone went remote. There's just (to me) no substitute for hallway chat, overhearing people arguing and getting involved, or coming across an interesting white boarding conversation. One person at a time talking on a scheduled webex is just not at all the same.
So it's possible, but it certainly _felt_ different than the random discussions I'd had at in-person companies.
I can't quite put my finger on it, though. With the remote startup, there was no choice...?
It's hard to have random conversations WFH when they're usually prefaced on running into someone in the hallway or saying a quick "hello" as you walk past their cubicle/office/whatever.