I had Safari/VoiceOver speak this tweet [0] (no offense to the author, it was just the first one in my feed that had this style of character in it). Every letter is some form of "Mathematical bold script capital s"
In that particular tweet, not only does it not read the word, but the "i" character is "Mathematical bold script small 1"
[0] https://twitter.com/kiwapebretech/status/1420613820876271617