> Carl C Pfeiffer
Pfeiffer "considered himself a founder of what [Linus Pauling] named orthomolecular psychiatry" - https://en.wikipedia.org/wiki/Carl_Pfeiffer_(pharmacologist)
> he blames the substance abuse on the histadelics
hmm? Searching for histadelics: "If youre lying in bed at night hoping for sleep, but your brain won't stop, this can be the chatter of histamine expressing itself. Histamine is metabolized through methylation. When histamine levels increase, the pool of available methyl donors can be depleted..." [0]
Oh, how helpful. Thanks, I hadn't really looked into this a whole lot. The old anti-histamine drug cyproheptadine is also an anti-serotonin drug, many people have problems with "serotonin syndrome" that are really helped with this safe prescription. Serotonin and histamine must have some important interaction, I'll have to look into this more.
Another interesting quote from [0] (my comments are sometimes my notes that I go back to...):
"An interesting and illustrative anecdote on folate and histamine was observed by the late Carl Pfeiffer, M.D. who was a leader in this field. He reported that he and his colleagues were puzzled that so many histadelic patients relapsed in the summer months. Eventually, the reason was found to lie in the increase of dietary folate that was found in green, leafy salad vegetables that people ate throughout the summer months."
[0] https://www.natures-source.com/blog/post/histadelia-a-primer...
> I'll try this levomefolic acid.
This site seemed useful when I ran across it a few months ago: https://mthfr.net/