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The counter-agent is that it's fictional. ;-) (We hope.)

Not necessarily in a satirical science fiction.

To prion diseases? Mainly in that they're not that common, more like a weird aberration than something that actively fights and adapts for its own survival like bacteria and viruses.

I mean cancer is not contagious, but it still kills millions a year.

Strictly speaking, contagious cancer is a thing, but not in humans. See https://en.wikipedia.org/wiki/Canine_transmissible_venereal_...

Yet.