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It would be a massive problem. IPV6 adoption and implementation was at a mere 33% (at least among Google users). [1]

[1] https://www.google.com/intl/en/ipv6/statistics.html

If you're behind a CDN, your origin can be pure IPv6

Then it doesn't matter whether you use ipv6 or ipv4 with the private 10.0.0.0/8 space either.

Yes! If you're behind ex. cloudflare, you should 100% look at running pure IPv6 with no listening ports, just their service locally.

Plenty. If you expect to access it from IPv4-only networks, you'll have to provide a gateway. Additionally, things like Docker interoperate very poorly with IPv6.

You want an IPv4 address if you want to be reachable by people.