I can't think of any other rasterizer than Freetype that has the option to enable hinting and then disable anti-aliasing. I've never tried that combination, what would be the point of that?
As screen resolutions rise, the need for hinting diminishes. On a 4K desktop monitor you still benefit from hinting. I think 8K desktop monitor resolution (at say 28 inch size) is probably where hinting loses relevance.
I don’t have a 4K desktop monitor but I was curious to see if it does anything with larger fonts. Trying it out with Open Sans and it does still give an increase in contrast on a 34px title font sample, but not as significant as on the smaller body text: https://cdn.knightlab.com/libs/juxtapose/latest/embed/index....