I generally suffer exclusively the singular negative effect of others finger wagging and disapproval of a rather pleasurable funcional vice or medication or whatever you wish to call it.
I’ve quit a few times for up to a year and always decided consciously to go back. One of the times I left tobacco behind. Countless studies will only ever have access to what users are willing to divulge, to the degree that it’s not an open regulated or at least informed market.
There is an interesting singular fact. Not one single overdose death has ever been conclusively linked to cannabis. The LD50 is something crazy like 15kg in the span of 15 minutes for a 75kg human.